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Biodegradable star HPMA polymer-drug conjugates: biodegradability, distribution and anti-tumor efficacy
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SYSNO ASEP 0363631 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Biodegradable star HPMA polymer-drug conjugates: biodegradability, distribution and anti-tumor efficacy Author(s) Etrych, Tomáš (UMCH-V) RID, ORCID
Kovář, Lubomír (MBU-M)
Strohalm, Jiří (UMCH-V)
Chytil, Petr (UMCH-V) RID, ORCID
Říhová, Blanka (MBU-M) RID
Ulbrich, Karel (UMCH-V) RIDSource Title Journal of Controlled Release. - : Elsevier - ISSN 0168-3659
Roč. 154, č. 3 (2011), s. 241-248Number of pages 8 s. Language eng - English Country NL - Netherlands Keywords star polymer ; HPMA copolymers ; drug release Subject RIV CD - Macromolecular Chemistry R&D Projects IAA400500806 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) IAAX00500803 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) GAP301/11/0325 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z40500505 - UMCH-V (2005-2011) AV0Z50200510 - MBU-M (2005-2011) UT WOS 000295503300005 DOI 10.1016/j.jconrel.2011.06.015 Annotation New biodegradable star polymer–doxorubicin conjugates designed for passive tumor targeting were investigated, and their synthesis, physico-chemical characterization, drug release, biodegradation, biodistribution and in vivo anti-tumor efficacy are described. In the conjugates, the core formed by poly(amidoamine) (PAMAM) dendrimers was grafted with semitelechelic N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers bearing doxorubicin (Dox) attached by hydrazone bonds, which enabled intracellular pH-controlled drug release. The described synthesis facilitated the preparation of biodegradable polymer conjugates in a broad range of molecular weights (200–1000 g/mol) while still maintaining low polydispersity (~ 1.7). The polymer grafts were attached to the dendrimers through either stable amide bonds or enzymatically or reductively degradable spacers, which enabled intracellular degradation of the high-molecular-weight polymer carrier to excretable products. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2012
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