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Oxidative stress and chromosomal aberrations in an environmentally exposed population
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SYSNO ASEP 0358218 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Oxidative stress and chromosomal aberrations in an environmentally exposed population Author(s) Rössner ml., Pavel (UEM-P) RID, ORCID
Rössnerová, Andrea (UEM-P) RID
Šrám, Radim (UEM-P) RIDSource Title Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. - : Elsevier - ISSN 0027-5107
Roč. 707, 1-2 (2011), s. 34-41Number of pages 8 s. Language eng - English Country NL - Netherlands Keywords air pollution ; oxidative stress ; chromosomal aberrations Subject RIV DN - Health Impact of the Environment Quality R&D Projects SP/1B3/8/08 GA MŽP - Ministry of Environment (MŽP) CEZ AV0Z50390512 - UEM-P (2005-2011) UT WOS 000287616600005 EID SCOPUS 79251595710 DOI 10.1016/j.mrfmmm.2010.12.005 Annotation The effect of seasonal variability of environmental air pollutants (c-PAHs and particulate matter PM2.5) on oxidative stress and cytogenetic biomarkes in a group of city policement from Prague was investigated. No significant difference between the two seasons (February and May 2007) for any biomarkers of oxidative stress (8-oxodG, 15-F2t-IsoP) or any cytogenetic parameter (genomic frequency of translocations – FG/100; % AB.C.; or the number of acentric fragments – ace) was observed. The effects of air pollution on all subjects regardless of the season was also studied. In summary, the results indicate that the exposure to environmental pollutants affects urinary excretion of 8-oxodG, lipid peroxidation and the frequency of chromosomal aberrations. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2011
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