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Molecular targets of the natural antioxidant pterostilbene: effect on protein kinase C, caspase-3 and apoptosis in human neutrophils in vitro

SYSNO ASEP	0356880
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Molecular targets of the natural antioxidant pterostilbene: effect on protein kinase C, caspase-3 and apoptosis in human neutrophils in vitro
Author(s)	Perečko, T. (SK) Drábiková, K. (SK) Račková, L. (SK) Číž, Milan (BFU-R)_{RID, ORCID} Podborská, Martina (BFU-R) Lojek, Antonín (BFU-R)_RID Harmatha, Juraj (UOCHB-X)_{RID, ORCID} Šmidrkal, J. (CZ) Nosál, R. (SK) Jančinová, V. (SK)
Number of authors	10
Source Title	Neuroendocrinology Letters - ISSN 0172-780X Roč. 31, č. 2 (2010), s. 84-90
Number of pages	7 s.
Language	eng - English
Country	SE - Sweden
Keywords	pterostilbene ; reactive oxygen species ; neutrophils
Subject RIV	BO - Biophysics
R&D Projects	OC08058 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	MEB0810013 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
CEZ	AV0Z50040507 - BFU-R (2005-2011)
	AV0Z50040702 - BFU-R (2007-2013)
	AV0Z40550506 - UOCHB-X (2005-2011)
UT WOS	000288061000016
Annotation	Pterostilbene, an analog of resveratrol, was identified as a good natural antioxidant compound. However, reducing the oxidative burst of human neutrophils during their activation in vitro with pterostilbene does not include protein kinase C phosphorylation pathway. Pterostilbene showed dose dependent activation/inhibition of caspase-3 enzyme activity.
Workplace	Institute of Biophysics
Contact	Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244
Year of Publishing	2011

Number of the records: 1