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Molecular targets of the natural antioxidant pterostilbene: effect on protein kinase C, caspase-3 and apoptosis in human neutrophils in vitro
- 1.0356880 - BFÚ 2011 RIV SE eng J - Journal Article
Perečko, T. - Drábiková, K. - Račková, L. - Číž, Milan - Podborská, Martina - Lojek, Antonín - Harmatha, Juraj - Šmidrkal, J. - Nosál, R. - Jančinová, V.
Molecular targets of the natural antioxidant pterostilbene: effect on protein kinase C, caspase-3 and apoptosis in human neutrophils in vitro.
Neuroendocrinology Letters. Roč. 31, č. 2 (2010), s. 84-90. ISSN 0172-780X. E-ISSN 2354-4716
R&D Projects: GA MŠMT(CZ) OC08058; GA MŠMT(CZ) MEB0810013
Grant - others:GA ČR(CZ) GA203/07/1227
Program: GA
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702; CEZ:AV0Z40550506
Keywords : pterostilbene * reactive oxygen species * neutrophils
Subject RIV: BO - Biophysics
Impact factor: 1.621, year: 2010
Pterostilbene, an analog of resveratrol, was identified as a good natural antioxidant compound. However, reducing the oxidative burst of human neutrophils during their activation in vitro with pterostilbene does not include protein kinase C phosphorylation pathway. Pterostilbene showed dose dependent activation/inhibition of caspase-3 enzyme activity.
Permanent Link: http://hdl.handle.net/11104/0195288
Number of the records: 1