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Immunogenicity and immunomodulatory properties of HPMA-based polymers
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SYSNO ASEP 0350356 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Immunogenicity and immunomodulatory properties of HPMA-based polymers Author(s) Říhová, Blanka (MBU-M) RID
Kovář, Marek (MBU-M) RID, ORCIDSource Title Advanced Drug Delivery Reviews. - : ELSEVIER SCIENCE BV - ISSN 0169-409X
Roč. 62, č. 2 (2010), s. 184-191Number of pages 8 s. Language eng - English Country NL - Netherlands Keywords Immunogenicity ; Hpma ; Immunomodulation Subject RIV EE - Microbiology, Virology R&D Projects KAN200200651 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) IAAX00500803 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) IAA500200712 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) 1M0505 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z50200510 - MBU-M (2005-2011) UT WOS 000275579900005 DOI 10.1016/j.addr.2009.10.005 Annotation In this study it was shown both in mice and humans that HPMA copolymer-bound doxorubicin (DOX-HPMA) conjugates possess besides powerfull anti-tumor effect also various immunomodulatory properties and exert significantly decreased side-toxicities, minimized bone marrow toxicity and cardiotoxicity being the most important ones. The possibility to induce potent and long-lasting tumor-specific immunity during the tratment with these compounds which is capable to provide protection against minimal residual disease is one of the most important and therapeutically valuable features of these conjugates Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2011
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