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Micellar and antibody-targeted polymer therapeutics
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SYSNO ASEP 0349044 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Micellar and antibody-targeted polymer therapeutics Author(s) Etrych, Tomáš (UMCH-V) RID, ORCID
Chytil, Petr (UMCH-V) RID, ORCID
Kovář, Lubomír (MBU-M)
Říhová, Blanka (MBU-M) RID
Ulbrich, Karel (UMCH-V) RIDSource Title Macromolecular Symposia. - : Wiley - ISSN 1022-1360
Roč. 295, - (2010), s. 1-12Number of pages 12 s. Action Prague Meetings on Macromolecules /73./ New Frontiers in Macromolecular Science: From Macromolecular Concepts of Living Matter to Polymers for Better Quality of Life Event date 05.07.2009-09.07.2009 VEvent location Prague Country CZ - Czech Republic Event type WRD Language eng - English Country DE - Germany Keywords doxorubicin ; drug delivery systems ; HPMA copolymers Subject RIV CD - Macromolecular Chemistry R&D Projects IAA400500806 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) IAAX00500803 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) 1M0505 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z40500505 - UMCH-V (2005-2011) AV0Z50200510 - MBU-M (2005-2011) UT WOS 000288038700001 DOI 10.1002/masy.200900066 Annotation Synthesis, physicochemical and some biological properties of new actively targeted antibody-containing and passively targeted micellar polymer - doxorubicin conjugates were investigated. Micellar HPMA-copolymer-based pharmaceuticals were prepared by self-assembly of copolymer–doxorubicin conjugates containing hydrophobic cholesterol ligands attached to the copolymer via hydrolytically degradable spacer. Synthesis of star antibody-targeted polymer conjugates takes advantage of reduction of disulfide bridges in antibody followed by conjugation with the semitelechelic copolymer. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2011
Number of the records: 1