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Chemical conjugation of cowpea mosaic viruses with reactive HPMA-based polymers
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SYSNO ASEP 0347069 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Chemical conjugation of cowpea mosaic viruses with reactive HPMA-based polymers Author(s) Laga, Richard (UMCH-V) RID, ORCID
Koňák, Čestmír (UMCH-V) RID
Šubr, Vladimír (UMCH-V) RID, ORCID
Ulbrich, Karel (UMCH-V) RID
Suthiwangcharoen, N. (US)
Niu, Q. (US)
Wang, Q. (US)Source Title Journal of Biomaterial Science Polymer Edition. - : Taylor & Francis - ISSN 0920-5063
Roč. 21, č. 12 (2010), s. 1669-1685Number of pages 17 s. Language eng - English Country NL - Netherlands Keywords acylthiazolidine-2-thione reactive groups ; bioconjugation ; coating Subject RIV CD - Macromolecular Chemistry R&D Projects KJB400500803 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) GA202/09/2078 GA ČR - Czech Science Foundation (CSF) KAN200200651 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z40500505 - UMCH-V (2005-2011) UT WOS 000282396800009 DOI 10.1163/092050609X12547435571131 Annotation N-(2-Hydroxypropyl)methacrylamide (HPMA) co-polymers containing disulfide and carbonyl thiazolidine-2-thione (TT) reactive groups in their side-chains (pHPMA-TT) were used as reductively removable chemical modification of the surface of cowpea mosaic viruses (CPMV). CPMV was used in this study as a model particle for viral gene delivery. The co-polymer reaction with CPMV surfaces carried out in aqueous solution was evaluated by monitoring the changes in the weight-average molecular weight and hydrodynamic size of the viruses using light scattering methods. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2011
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