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Chemical conjugation of cowpea mosaic viruses with reactive HPMA-based polymers
- 1.0347069 - ÚMCH 2011 RIV NL eng J - Journal Article
Laga, Richard - Koňák, Čestmír - Šubr, Vladimír - Ulbrich, Karel - Suthiwangcharoen, N. - Niu, Q. - Wang, Q.
Chemical conjugation of cowpea mosaic viruses with reactive HPMA-based polymers.
Journal of Biomaterial Science Polymer Edition. Roč. 21, č. 12 (2010), s. 1669-1685. ISSN 0920-5063. E-ISSN 1568-5624
R&D Projects: GA AV ČR KJB400500803; GA ČR GA202/09/2078; GA AV ČR KAN200200651
Institutional research plan: CEZ:AV0Z40500505
Keywords : acylthiazolidine-2-thione reactive groups * bioconjugation * coating
Subject RIV: CD - Macromolecular Chemistry
Impact factor: 1.842, year: 2010
N-(2-Hydroxypropyl)methacrylamide (HPMA) co-polymers containing disulfide and carbonyl thiazolidine-2-thione (TT) reactive groups in their side-chains (pHPMA-TT) were used as reductively removable chemical modification of the surface of cowpea mosaic viruses (CPMV). CPMV was used in this study as a model particle for viral gene delivery. The co-polymer reaction with CPMV surfaces carried out in aqueous solution was evaluated by monitoring the changes in the weight-average molecular weight and hydrodynamic size of the viruses using light scattering methods.
Permanent Link: http://hdl.handle.net/11104/0006004
Number of the records: 1