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Toward the insulin-IGF-I intermediate structures: Functional and structural properties of the [TyrB25NMePheB26] insulin mutant
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SYSNO ASEP 0102994 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Toward the insulin-IGF-I intermediate structures: Functional and structural properties of the [TyrB25NMePheB26] insulin mutant Title Insulin/IGF-I mezistruktura: funkční a strukturní vlastnosti mutantu insulinu [TyrB25NMePheB26] Author(s) Žáková, Lenka (UOCHB-X) RID, ORCID
Brynda, Jiří (UMG-J) RID
Au-Alvarez, O. (CU)
Dodson, G. D. (GB)
Whittingham, J. L. (GB)
Brzozowski, A. M. (GB)Source Title Biochemistry. - : American Chemical Society - ISSN 0006-2960
Roč. 43, - (2004), s. 16293-16300Number of pages 8 s. Language eng - English Country US - United States Keywords insulin ; IGF-I ; Structures Subject RIV CE - Biochemistry R&D Projects LN00B030 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z4055905 - UOCHB-X Annotation Insulin analogue with IGF-I-like structural features has been synthesized. Insulin residues PheB25 and TyrB26 have been swapped with the IGF-I-like Tyr24 and Phe25 sequence with a simultaneous methylation of the peptide nitrogen of residue PheB26 Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434 Year of Publishing 2005
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