0102994 - UOCHB-X 20043386 RIV US eng J - Journal Article
Žáková, Lenka - Brynda, Jiří - Au-Alvarez, O. - Dodson, G. D. - Whittingham, J. L. - Brzozowski, A. M.
Toward the insulin-IGF-I intermediate structures: Functional and structural properties of the [TyrB25NMePheB26] insulin mutant.
[Insulin/IGF-I mezistruktura: funkční a strukturní vlastnosti mutantu insulinu [TyrB25NMePheB26].]
Biochemistry. Roč. 43, - (2004), s. 16293-16300. ISSN 0006-2960. E-ISSN 1520-4995
R&D Projects: GA MŠMT LN00B030
Institutional research plan: CEZ:AV0Z4055905
Keywords : insulin * IGF-I * Structures
Subject RIV: CE - Biochemistry
Impact factor: 4.008, year: 2004

Insulin analogue with IGF-I-like structural features has been synthesized. Insulin residues PheB25 and TyrB26 have been swapped with the IGF-I-like Tyr24 and Phe25 sequence with a simultaneous methylation of the peptide nitrogen of residue PheB26

Byl syntetizován analog insulinu se strukturálními vlastnostmi podobnými IGF-I. Aminokyseliny PheB25 a TyrB26 insulinu byly zaměněny v sekvenci podobnou IGF-I s Tyr24 a Phe25 a současnou methylací peptidové vazby aminokyseliny PheB26
Permanent Link: http://hdl.handle.net/11104/0010327