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100 million years of multigene family evolution: origin and evolution of the avian MHC class IIB
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SYSNO ASEP 0475331 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title 100 million years of multigene family evolution: origin and evolution of the avian MHC class IIB Author(s) Goebel, J. (CH)
Promerová, Marta (UBO-W)
Bonadonna, F. (FR)
McCoy, K. D. (FR)
Serbielle, C. (FR)
Strandh, M. (FR)
Yannic, G. (FR)
Burri, R. (DE)
Fumagalli, L. (CH)Number of authors 9 Source Title BMC Genomics. - : BioMed Central - ISSN 1471-2164
Roč. 18, č. 460 (2017), s. 1-9Number of pages 9 s. Language eng - English Country GB - United Kingdom Keywords Birds ; Birth-death evolution ; Concerted evolution ; Gene duplication ; Gene conversion ; Major histocompatibility complex ; Recombination Subject RIV EG - Zoology OECD category Genetics and heredity (medical genetics to be 3) R&D Projects GAP505/10/1871 GA ČR - Czech Science Foundation (CSF) Institutional support UBO-W - RVO:68081766 UT WOS 000413749900001 EID SCOPUS 85020646288 DOI https://doi.org/10.1186/s12864-017-3839-7 Annotation Background: Gene duplication has led to a most remarkable adaptation involved in vertebrates’ host-pathogen arms-race, the major histocompatibility complex (MHC). However, MHC duplication history is as yet poorly understood in non-mammalian vertebrates, including birds.
Results: Here, we provide evidence for the evolution of two ancient avian MHC class IIB (MHCIIB) lineages by a duplication event prior to the radiation of all extant birds >100 million years ago, and document the role of concerted evolution in eroding the footprints of the avian MHCIIB duplication history.
Conclusions: Our results suggest that eroded footprints of gene duplication histories may mimic birth-death evolution and that in the avian MHC the presence of the two lineages may have been masked by elevated rates of concerted evolution in several taxa. Through the presence of a range of intermediate evolutionary stages along the homogenizing process of concerted evolution, the avian MHCIIB provides a remarkable illustration of the erosion of multigene family duplication history.Workplace Institute of Vertebrate Biology Contact Hana Slabáková, slabakova@ivb.cz, Tel.: 543 422 524 Year of Publishing 2018
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