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In vitro cytotoxicity evaluation of organotin(IV) complexes derived from bisphosphoramide ligand: DNA binding and molecular docking studies
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SYSNO ASEP 0577711 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title In vitro cytotoxicity evaluation of organotin(IV) complexes derived from bisphosphoramide ligand: DNA binding and molecular docking studies Author(s) Pooyan, M. (IR)
Shariatinia, Z. (IR)
Mohammadpanah, F. (IR)
Gholivand, K. (IR)
Dušek, Michal (FZU-D) RID, ORCID, SAI
Eigner, Václav (FZU-D) RID, ORCID
Satari, M. (IR)
Ebrahimi Valmoozi, A.A. (IR)Number of authors 8 Article number 123442 Source Title Journal of Molecular Liquids. - : Elsevier - ISSN 0167-7322
Roč. 13, Dec (2023)Number of pages 16 s. Language eng - English Country NL - Netherlands Keywords organotin(IV) complexes ; bisphosphoramide ligands ; molecular docking ; cytotoxicity ; DNA binding ; anticancer activity Subject RIV BM - Solid Matter Physics ; Magnetism OECD category Condensed matter physics (including formerly solid state physics, supercond.) R&D Projects LM2018110 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Limited access Institutional support FZU-D - RVO:68378271 UT WOS 001105654500001 EID SCOPUS 85175309373 DOI https://doi.org/10.1016/j.molliq.2023.123442 Annotation Considering the valuable position of organotins and the biotic role of phosphorus compounds in biological processes, in this research work, we investigated and introduced a new class of anticancer candidates based on organotin(IV) complexes derived from bisphosphoramide ligands. Four selected complexes were prepared from the reaction of SnMe2Cl2 (C1), SnBu3Cl (C2), SnPh2Cl2 (C3), and SnPh3Cl (C4) metal salts with piperazine-1,4-diylbis(diphenylphosphine oxide) ligand (LP). The newly synthesized complexes were characterized using spectroscopic techniques. Single crystal of C1 structure was determined by X-ray crystallography. Binding potentials of compounds to DNA were also explored using electron absorption titration and competitive fluorescence quenching techniques, which indicated that complexes and CT-DNA strongly interacted. Workplace Institute of Physics Contact Kristina Potocká, potocka@fzu.cz, Tel.: 220 318 579 Year of Publishing 2024 Electronic address https://doi.org/10.1016/j.molliq.2023.123442
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