0577711 - FZÚ 2024 RIV NL eng J - Journal Article
Pooyan, M. - Shariatinia, Z. - Mohammadpanah, F. - Gholivand, K. - Dušek, Michal - Eigner, Václav - Satari, M. - Ebrahimi Valmoozi, A.A.
In vitro cytotoxicity evaluation of organotin(IV) complexes derived from bisphosphoramide ligand: DNA binding and molecular docking studies.
Journal of Molecular Liquids. Roč. 13, Dec (2023), č. článku 123442. ISSN 0167-7322. E-ISSN 1873-3166
R&D Projects: GA MŠMT LM2018110
Institutional support: RVO:68378271
Keywords : organotin(IV) complexes * bisphosphoramide ligands * molecular docking * cytotoxicity * DNA binding * anticancer activity
OECD category: Condensed matter physics (including formerly solid state physics, supercond.)
Impact factor: 5.3, year: 2023
Method of publishing: Limited access
https://doi.org/10.1016/j.molliq.2023.123442

Considering the valuable position of organotins and the biotic role of phosphorus compounds in biological processes, in this research work, we investigated and introduced a new class of anticancer candidates based on organotin(IV) complexes derived from bisphosphoramide ligands. Four selected complexes were prepared from the reaction of SnMe2Cl2 (C1), SnBu3Cl (C2), SnPh2Cl2 (C3), and SnPh3Cl (C4) metal salts with piperazine-1,4-diylbis(diphenylphosphine oxide) ligand (LP). The newly synthesized complexes were characterized using spectroscopic techniques. Single crystal of C1 structure was determined by X-ray crystallography. Binding potentials of compounds to DNA were also explored using electron absorption titration and competitive fluorescence quenching techniques, which indicated that complexes and CT-DNA strongly interacted.
Permanent Link: https://hdl.handle.net/11104/0346828