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Evaluation of silica from different vendors as the solid support of anion-exchange chiral stationary phases by means of preferential sorption and liquid chromatography.
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SYSNO ASEP 0511718 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Evaluation of silica from different vendors as the solid support of anion-exchange chiral stationary phases by means of preferential sorption and liquid chromatography. Author(s) Kohout, P. (CZ)
Hovorka, Š. (CZ)
Herciková, J. (CZ)
Wilk, M. (CZ)
Sysel, P. (CZ)
Izák, Pavel (UCHP-M) RID, ORCID, SAI
Bartůněk, V. (CZ)
von Baeckmann, C. (AT)
Pícha, Jan (UOCHB-X) RID, ORCID
Frühauf, P. (AT)Source Title Journal of Separation Science. - : Wiley - ISSN 1615-9306
Roč. 42, č. 24 (2019), s. 3653-3661Number of pages 9 s. Language eng - English Country DE - Germany Keywords chiral anion exchanger ; preferential sorption ; liquid chromatography Subject RIV CI - Industrial Chemistry, Chemical Engineering OECD category Chemical process engineering Subject RIV - cooperation Institute of Organic Chemistry and Biochemistry - Analytical Chemistry, Separation R&D Projects GA17-00089S GA ČR - Czech Science Foundation (CSF) Method of publishing Limited access Institutional support UCHP-M - RVO:67985858 ; UOCHB-X - RVO:61388963 UT WOS 000493821900001 EID SCOPUS 85074777197 DOI 10.1002/jssc.201900731 Annotation Chromatographic performance of a chiral stationary phase is significantly influenced by the employed solid support. Properties of the most commonly used support, silica particles, such as size and size distribution, and pore size are of utmost importance for both superficially porous particles and fully porous particles. In this work, we have focused on evaluation of fully porous particles from three different vendors as solid supports for a brush-type chiral stationary phase based on 9-O-tert-butylcarbamoyl quinidine. We have prepared corresponding stationary phases under identical experimental conditions and determined the parameters of the modified silica by physisorption measurements and scanning electron microscopy. Enantiorecognition properties of the chiral stationary phases have been studied using preferential sorption experiments. The same material was slurry-packed into chromatographic columns and the chromatographic properties have been evaluated in liquid chromatography. We show that preferential sorption can provide valuable information about the influence of the pore size and total pore volume on the interaction of analytes of different size with the chirally-modified silica surface. The data can be used to understand differences observed in chromatographic evaluation of the chiral stationary phases. The combination of preferential sorption and liquid chromatography separation can provide detailed information on new chiral stationary phases. Workplace Institute of Chemical Process Fundamentals Contact Eva Jirsová, jirsova@icpf.cas.cz, Tel.: 220 390 227 Year of Publishing 2020 Electronic address http://hdl.handle.net/11104/0303439
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