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Synergistic effect of HPMA copolymer-bound doxorubicin and dexamethasone in vivo on mouse lymphomas
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SYSNO ASEP 0359969 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Synergistic effect of HPMA copolymer-bound doxorubicin and dexamethasone in vivo on mouse lymphomas Author(s) Kostková, Hana (UMCH-V) RID
Etrych, Tomáš (UMCH-V) RID, ORCID
Říhová, Blanka (MBU-M) RID
Ulbrich, Karel (UMCH-V) RIDSource Title Journal of Bioactive and Compatible Polymers. - : Sage - ISSN 0883-9115
Roč. 26, č. 3 (2011), s. 270-286Number of pages 17 s. Language eng - English Country GB - United Kingdom Keywords HPMA copolymer ; doxorubicin ; dexamethasone Subject RIV CD - Macromolecular Chemistry R&D Projects IAAX00500803 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) IAA400500806 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) 1M0505 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z40500505 - UMCH-V (2005-2011) AV0Z50200510 - MBU-M (2005-2011) UT WOS 000290949300004 DOI 10.1177/0883911511406326 Annotation N-(2-Hydroxypropyl)methacrylamide copolymer—drug conjugates bearing the antiinflammatory and anti-proliferative drug dexamethasone (DEX) and the anti-cancer drug doxorubicin (DOX) bound to either the polymer carrier separately or in combination, were synthesized. Both the in vitro and in vivo anti-cancer activity on mouse B-cell (38C13) and T-cell (EL4) lymphoma was studied. The conjugates were fairly stable in model buffers at pH 7.4, simulating blood pH, and the drug was released by chemical hydrolysis at pH values based on the endosomal and lysosomal environments in the target cells (pH 5—6).Contrary to the treatment with either single drug conjugate, where no significant long-term survival was observed, a synergistic effect of the two drugs was manifested in vivo. Treatment of mice bearing B-cell lymphoma 38C13 formulated as a mixture of both single drug-containing conjugates or a as a conjugate with both drugs in combination gave long-term survivors. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2012
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