Carboxylated calixarenes bind strongly to CD69 and protect CD69+ killer cells from suicidal cell death induced by tumor cell surface ligands

Bezouška, K.; Šnajdrová, R.; Křenek, K.; Vančurová, Markéta; Kádek, A.; Adámek, D.; Lhoták, P.; Kavan, Daniel; Hofbauerová, Kateřina; Man, Petr; Bojarová, Pavla; Křen, Vladimír

doi:https://dx.doi.org/10.1016/j.bmc.2010.01.015

Number of the records: 1

Carboxylated calixarenes bind strongly to CD69 and protect CD69+ killer cells from suicidal cell death induced by tumor cell surface ligands

1.

SYSNO ASEP	0350689
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Carboxylated calixarenes bind strongly to CD69 and protect CD69+ killer cells from suicidal cell death induced by tumor cell surface ligands
Author(s)	Bezouška, K. (CZ) Šnajdrová, R. (CZ) Křenek, K. (CZ) Vančurová, Markéta (MBU-M) Kádek, A. (CZ) Adámek, D. (CZ) Lhoták, P. (CZ) Kavan, Daniel (MBU-M)_{RID, ORCID} Hofbauerová, Kateřina (MBU-M)_ORCID Man, Petr (MBU-M)_{RID, ORCID} Bojarová, Pavla (MBU-M)_ORCID Křen, Vladimír (MBU-M)_{RID, ORCID}
Source Title	Bioorganic & Medicinal Chemistry. - : Elsevier - ISSN 0968-0896 Roč. 18, č. 4 (2010), s. 1434-1440
Number of pages	7 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	Carboxylated calixarenes ; Lymphocyte activation ; Receptor cross-linking
Subject RIV	CE - Biochemistry
R&D Projects	OC 136 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	1M0505 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	GA303/09/0477 GA ČR - Czech Science Foundation (CSF)
	GD305/09/H008 GA ČR - Czech Science Foundation (CSF)
	IAA400200503 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
	KJB500200612 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
CEZ	AV0Z50200510 - MBU-M (2005-2011)
UT WOS	000274425500008
DOI	10.1016/j.bmc.2010.01.015
Annotation	We have recently identified a new class of high affinity ligands for CD69 leukocyte membrane receptor, carboxylated calixarenes. Of the three compounds investigated here, thiacalix[4]arene had the highest affinity for CD69 in direct binding assays, and proved to be the most specific inhibitor of CD69 identified so far in receptor precipitation and cellular activation experiments. Carboxylated calixarenes also proved effective at protection of CD69(high) lymphocytes from apoptosis triggered by a multivalent ligand or antibody. Thus, carboxylated calixarenes set a new paradigm for noncarbohydrate ligands for CD69 making them attractive for protection of killer cells in combined animal tumor therapies
Workplace	Institute of Microbiology
Contact	Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231
Year of Publishing	2011

Number of the records: 1