New in vitro reporter gene bioassays for screening of hormonal active compounds in the environment

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SYSNO ASEP	0348168
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	New in vitro reporter gene bioassays for screening of hormonal active compounds in the environment
Author(s)	Svobodová, Kateřina (MBU-M)_RID Cajthaml, Tomáš (MBU-M)_{RID, ORCID}
Source Title	Applied Microbiology and Biotechnology. - : Springer - ISSN 0175-7598 Roč. 88, č. 4 (2010), s. 839-847
Number of pages	9 s.
Language	eng - English
Country	DE - Germany
Keywords	endocrine disruptors ; in vitro bioassays ; reporter gene assays
Subject RIV	EE - Microbiology, Virology
R&D Projects	GAP503/10/0408 GA ČR - Czech Science Foundation (CSF)
CEZ	AV0Z50200510 - MBU-M (2005-2011)
UT WOS	000282123800004
DOI	10.1007/s00253-010-2833-7
Annotation	Identification of chemicals with endocrinedisrupting activities in the past two decades has led to the need for sensitive assays for detection and monitoring of these activities in the environment. In vitro reporter gene assays represent a relatively fast and easy-to-perform method for detection of compounds that are able to bind to hormonal receptors and stimulate or silence their transactivation activity, thus interfering with the hormone signaling pathways. This paper reviews upgrades on reporter gene assays performed during the last decade
Workplace	Institute of Microbiology
Contact	Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231
Year of Publishing	2011

Number of the records: 1