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New in vitro reporter gene bioassays for screening of hormonal active compounds in the environment
- 1.0348168 - MBÚ 2011 RIV DE eng J - Journal Article
Svobodová, Kateřina - Cajthaml, Tomáš
New in vitro reporter gene bioassays for screening of hormonal active compounds in the environment.
Applied Microbiology and Biotechnology. Roč. 88, č. 4 (2010), s. 839-847. ISSN 0175-7598. E-ISSN 1432-0614
R&D Projects: GA ČR GAP503/10/0408
Institutional research plan: CEZ:AV0Z50200510
Keywords : endocrine disruptors * in vitro bioassays * reporter gene assays
Subject RIV: EE - Microbiology, Virology
Impact factor: 3.280, year: 2010
Identification of chemicals with endocrinedisrupting activities in the past two decades has led to the need for sensitive assays for detection and monitoring of these activities in the environment. In vitro reporter gene assays represent a relatively fast and easy-to-perform method for detection of compounds that are able to bind to hormonal receptors and stimulate or silence their transactivation activity, thus interfering with the hormone signaling pathways. This paper reviews upgrades on reporter gene assays performed during the last decade
Permanent Link: http://hdl.handle.net/11104/0188766
Number of the records: 1