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Cell adhesion on artificial materials for tissue engineering
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SYSNO ASEP 0104195 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Cell adhesion on artificial materials for tissue engineering Title Adhese buněk na umělých materiálech pro tkáňové inženýrství Author(s) Bačáková, Lucie (FGU-C) RID, ORCID
Filová, Elena (FGU-C) RID, ORCID
Rypáček, František (UMCH-V) RID
Švorčík, V. (CZ)
Starý, V. (CZ)Source Title Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408
Roč. 53, Suppl. 1 (2004), S35-S45Number of pages 11 s. Language eng - English Country CZ - Czech Republic Keywords biomaterials ; bioinert ; bioactive Subject RIV EI - Biotechnology ; Bionics R&D Projects IAA5011301 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) IAA4050202 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) GA304/02/1348 GA ČR - Czech Science Foundation (CSF) OC 527.130 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z5011922 - FGU-C Annotation Advanced interdisciplinary scientific field of tissue engineering has been developed to meet increasing demand for safe, functional and easy available substitutes of irreversibly damaged tissues and organs. First biomaterials were constructed as two-dimensional (allowing cell adhesion only on their surface), and durable (non-biodegradable). In contrast, biomaterials of new generation are characterized by so-called three dimensional porous or scaffold-like architecture promoting attachment, growth and differentiation of cells inside the material, accompanied by its gradual removal and replacement with regenerated fully functional tissue. In order to control these processes, these materials are endowed with a defined spectrum of bioactive molecules, such as ligands for adhesion receptors on cells, functional parts of natural growth factors, hormones and enzymes or synthetic regulators of cell behavior. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2005
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