Immunological activity of HPMA copolymer-bound doxorubicincontaining human immunoglobulin: experimental and clinicaldata

Šírová, Milada; Strohalm, Jiří; Kubáčková, K.; Rozprimová, L.; Jelínková, Markéta; Kovář, Marek; Mrkvan, Tomáš; Pokorná, J.; Renčiuk, Daniel; Etrych, Tomáš; Ulbrich, Karel; Říhová, Blanka

Number of the records: 1

Immunological activity of HPMA copolymer-bound doxorubicincontaining human immunoglobulin: experimental and clinicaldata

1.

SYSNO ASEP	0100369
Document Type	C - Proceedings Paper (int. conf.)
R&D Document Type	Conference Paper
Title	Immunological activity of HPMA copolymer-bound doxorubicincontaining human immunoglobulin: experimental and clinicaldata
Title	Imunologická aktivita doxorubicinu navázaného na HPMA obsahujícího imunoglobulin: experimentální a klinická data
Author(s)	Šírová, Milada (MBU-M)_{RID, ORCID} Strohalm, Jiří (UMCH-V) Kubáčková, K. (CZ) Rozprimová, L. (CZ) Jelínková, Markéta (MBU-M) Kovář, Marek (MBU-M)_{RID, ORCID} Mrkvan, Tomáš (MBU-M) Pokorná, J. (CZ) Renčiuk, Daniel (MBU-M) Etrych, Tomáš (UMCH-V)_{RID, ORCID} Ulbrich, Karel (UMCH-V)_RID Říhová, Blanka (MBU-M)_RID
Source Title	International Symposium on Tumor Targeted delivery Systems /2./. - Maryland, 2003
Pages	s. 262-264
Number of pages	3 s.
Action	International Symposium on Tumor Targeted Delivery Systems /2./
Event date	23.09.2002-25.09.2002
VEvent location	Maryland
Country	US - United States
Event type	WRD
Language	eng - English
Country	US - United States
Keywords	hpma ; nk
Subject RIV	EE - Microbiology, Virology
R&D Projects	GA305/02/1425 GA ČR - Czech Science Foundation (CSF)
	GA310/99/P020 GA ČR - Czech Science Foundation (CSF)
	IBS5020101 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
	IAA4050201 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
CEZ	AV0Z5020903 - MBU-M
Annotation	Natural killer (NK) and lymphokine-activated killer (LAK) activity was studied during the therapy of 4 patients with generalized breast cancer, resistant to standard chemotherapy, treated with N-(2-hydroxypropyl)methacrylamide copolymer-bound doxorubicin conjugated with human immunoglobulin as the targeting moiety. Increased levels of NK and LAK activity in peripheral blood were found in two of the four patients. In either patient, no significant markers of systemic toxicity of Dox were recorded.
Workplace	Institute of Microbiology
Contact	Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231
Year of Publishing	2005

Number of the records: 1