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G4Killer web application: a tool to design G-quadruplex mutations
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SYSNO ASEP 0539893 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title G4Killer web application: a tool to design G-quadruplex mutations Author(s) Brázda, Václav (BFU-R) RID, ORCID
Kolomaznik, J. (CZ)
Mergny, Jean-Louis (BFU-R) ORCID, RID
Šťastný, J. (CZ)Number of authors 4 Source Title Bioinformatics. - : Oxford University Press - ISSN 1367-4803
Roč. 36, č. 10 (2020), s. 3246-3247Number of pages 2 s. Publication form Print - P Language eng - English Country GB - United Kingdom Keywords G4Killer ; web application ; G-quadruplex mutations Subject RIV CE - Biochemistry OECD category Biochemistry and molecular biology R&D Projects GA18-15548S GA ČR - Czech Science Foundation (CSF) EF15_003/0000477 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Open access Institutional support BFU-R - RVO:68081707 UT WOS 000537447900040 EID SCOPUS 85084694274 DOI 10.1093/bioinformatics/btaa057 Annotation Motivation: G-quadruplexes (G4) are important regulatory non-B DNA structures with therapeutic potential. A tool for rational design of mutations leading to decreased propensity for G4 formation should be useful in studying G4 functions. Although tools exist for G4 prediction, no easily accessible tool for the rational design of G4 mutations has been available. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2021 Electronic address https://academic.oup.com/bioinformatics/article/36/10/3246/5716328
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