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Membrane-Cytoskeleton Dynamics in the Course of Mast Cell Activation
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SYSNO ASEP 0442474 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Membrane-Cytoskeleton Dynamics in the Course of Mast Cell Activation Author(s) Dráber, Pavel (UMG-J) RID, ORCID
Dráber, Petr (UMG-J) RIDSource Title Methods in Molecular Biology. - : Humana Press - ISSN 1064-3745
Roč. 1220, č. 1 (2015), s. 219-237Number of pages 19 s. Language eng - English Country US - United States Keywords mast cells ; plasma membrane ; actin Subject RIV EB - Genetics ; Molecular Biology R&D Projects GA204/09/1777 GA ČR - Czech Science Foundation (CSF) GA14-09807S GA ČR - Czech Science Foundation (CSF) GA14-00703S GA ČR - Czech Science Foundation (CSF) GBP302/12/G101 GA ČR - Czech Science Foundation (CSF) LC545 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) LD12073 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) LD13015 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) KAN200520701 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) M200520901 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) Institutional support UMG-J - RVO:68378050 UT WOS 000345968400015 DOI 10.1007/978-1-4939-1568-2 Annotation Aggregation of the high-affinity IgE receptor (Fc epsilon RI) on the plasma membrane of mast cells and basophils initiates signaling events leading to a rapid release of preformed inflammatory mediators from secretory granules, and overall changes in cell morphology. Mast cell activation also causes reorganization of cytoskeletal components associated with membrane ruffling, spreading, and migration. Here we describe methods used for visualization of mast cell cytoskeleton, focusing on its two major components, microfilaments and microtubules, and their changes after cell triggering. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2015
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