Membrane-Cytoskeleton Dynamics in the Course of Mast Cell Activation

0442474 - ÚMG 2015 RIV US eng J - Journal Article
Dráber, Pavel - Dráber, Petr
Membrane-Cytoskeleton Dynamics in the Course of Mast Cell Activation.
Methods in Molecular Biology. Roč. 1220, č. 1 (2015), s. 219-237. ISSN 1064-3745
R&D Projects: GA ČR GA204/09/1777; GA ČR(CZ) GA14-09807S; GA ČR(CZ) GA14-00703S; GA ČR(CZ) GBP302/12/G101; GA MŠMT LC545; GA MŠMT LD12073; GA MŠMT(CZ) LD13015; GA AV ČR KAN200520701; GA AV ČR(CZ) M200520901
Institutional support: RVO:68378050
Keywords : mast cells * plasma membrane * actin
Subject RIV: EB - Genetics ; Molecular Biology

Aggregation of the high-affinity IgE receptor (Fc epsilon RI) on the plasma membrane of mast cells and basophils initiates signaling events leading to a rapid release of preformed inflammatory mediators from secretory granules, and overall changes in cell morphology. Mast cell activation also causes reorganization of cytoskeletal components associated with membrane ruffling, spreading, and migration. Here we describe methods used for visualization of mast cell cytoskeleton, focusing on its two major components, microfilaments and microtubules, and their changes after cell triggering.
Permanent Link: http://hdl.handle.net/11104/0245287