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The healing of alkali-injured cornea is stimulated by a novel matrix regenerating agent (RGTA, CACICOL20) – a biopolymer mimicking heparan sulfates reducing proteolytic, oxidative and nitrosative damage
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SYSNO ASEP 0398231 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title The healing of alkali-injured cornea is stimulated by a novel matrix regenerating agent (RGTA, CACICOL20) – a biopolymer mimicking heparan sulfates reducing proteolytic, oxidative and nitrosative damage Author(s) Čejková, Jitka (UEM-P) RID
Olmiere, C. (FR)
Čejka, Čestmír (UEM-P) RID
Trošan, Peter (UEM-P)
Holáň, Vladimír (UEM-P) RIDNumber of authors 5 Source Title Histology and Histopathology. - : Universidad de Murcia - ISSN 0213-3911
Roč. 29, č. 4 (2014), s. 457-478Number of pages 22 s. Language eng - English Country ES - Spain Keywords RGTA ; alkali injury ; corneal healing Subject RIV FF - HEENT, Dentistry R&D Projects GAP304/11/0653 GA ČR - Czech Science Foundation (CSF) Institutional support UEM-P - RVO:68378041 CEZ AV0Z50390512 - UEM-P (2005-2011) UT WOS 000333756800006 EID SCOPUS 84897046223 Annotation Heparan sulfate mimicking regeneration agent (RGTA) enabled the healing of the rabbit cornea, injured with highly concentrated alkali. When RGTA was applied by dropping on the damaged cornea early after the injury, it highly suppresed the development of corneal ulcerative processes. When the damaged cornea was topically treated with RGTA later after the injury – during the occurence of corneal ulcers, it healed majority of them. The healing of the alkali-injured cornea by RGTA took place due to the reduction of proteolytic, oxidative and nitrosative damage. key words (3): RGTA, alkali injury, corneal healing Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2015
Number of the records: 1