Number of the records: 1
The healing of alkali-injured cornea is stimulated by a novel matrix regenerating agent (RGTA, CACICOL20) – a biopolymer mimicking heparan sulfates reducing proteolytic, oxidative and nitrosative damage
- 1.0398231 - ÚEM 2015 RIV ES eng J - Journal Article
Čejková, Jitka - Olmiere, C. - Čejka, Čestmír - Trošan, Peter - Holáň, Vladimír
The healing of alkali-injured cornea is stimulated by a novel matrix regenerating agent (RGTA, CACICOL20) – a biopolymer mimicking heparan sulfates reducing proteolytic, oxidative and nitrosative damage.
Histology and Histopathology. Roč. 29, č. 4 (2014), s. 457-478. ISSN 0213-3911. E-ISSN 1699-5848
R&D Projects: GA ČR GAP304/11/0653
Institutional research plan: CEZ:AV0Z50390512
Institutional support: RVO:68378041
Keywords : RGTA * alkali injury * corneal healing
Subject RIV: FF - HEENT, Dentistry
Impact factor: 2.096, year: 2014
Heparan sulfate mimicking regeneration agent (RGTA) enabled the healing of the rabbit cornea, injured with highly concentrated alkali. When RGTA was applied by dropping on the damaged cornea early after the injury, it highly suppresed the development of corneal ulcerative processes. When the damaged cornea was topically treated with RGTA later after the injury – during the occurence of corneal ulcers, it healed majority of them. The healing of the alkali-injured cornea by RGTA took place due to the reduction of proteolytic, oxidative and nitrosative damage. key words (3): RGTA, alkali injury, corneal healing
Permanent Link: http://hdl.handle.net/11104/0233917
Number of the records: 1