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Fine needle aspiration biopsy proves increased T-lymphocyte proliferation in tumor and decreased metastatic infiltration after treatment with doxorubicin bound to PHPMA copolymer carrier
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SYSNO ASEP 0396051 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Fine needle aspiration biopsy proves increased T-lymphocyte proliferation in tumor and decreased metastatic infiltration after treatment with doxorubicin bound to PHPMA copolymer carrier Author(s) Betka, Jaroslav (MBU-M)
Hovorka, Ondřej (MBU-M)
Bouček, Jan (MBU-M)
Ulbrich, Karel (UMCH-V) RID
Etrych, Tomáš (UMCH-V) RID, ORCID
Říhová, Blanka (MBU-M) RIDSource Title Journal of Drug Targeting - ISSN 1061-186X
Roč. 21, č. 7 (2013), s. 648-661Number of pages 14 s. Language eng - English Country GB - United Kingdom Keywords Doxorubicin conjugates ; Drug targeting ; Fine needle aspiration biopsy Subject RIV EE - Microbiology, Virology Subject RIV - cooperation Institute of Macromolecular Chemistry - Macromolecular Chemistry R&D Projects GAP301/12/1254 GA ČR - Czech Science Foundation (CSF) Institutional support MBU-M - RVO:61388971 ; UMCH-V - RVO:61389013 UT WOS 000322070200004 DOI 10.3109/1061186X.2013.792345 Annotation First, mice were inoculated with mouse T-lymphoma, after 10 d the samples from tumor, lymph nodes and spleen gained by FNAB and excision were analyzed by flow cytometry. Tumor progression was compared to the control group simultaneously. Then, 10 d after tumor cell inoculation free doxorubicin (DOX) or different PHPMA DOX conjugates were injected. Cell material was analyzed to detect subpopulations of lymphocyte infiltrate, and levels of cytokines in correlation with progression or regression of the disease Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2014
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