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High-molecular-weight polymers containing biodegradable disulfide bonds: synthesis and in vitro verification of intracellular degradation
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SYSNO ASEP 0338553 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title High-molecular-weight polymers containing biodegradable disulfide bonds: synthesis and in vitro verification of intracellular degradation Author(s) Etrych, Tomáš (UMCH-V) RID, ORCID
Kovář, Lubomír (MBU-M)
Šubr, Vladimír (UMCH-V) RID, ORCID
Braunová, Alena (UMCH-V) RID
Pechar, Michal (UMCH-V) RID, ORCID
Chytil, Petr (UMCH-V) RID, ORCID
Říhová, Blanka (MBU-M) RID
Ulbrich, Karel (UMCH-V) RIDSource Title Journal of Bioactive and Compatible Polymers. - : Sage - ISSN 0883-9115
Roč. 25, č. 1 (2010), s. 5-26Number of pages 22 s. Language eng - English Country GB - United Kingdom Keywords water-soluble polymers ; reductive degradation ; HPMA copolymers Subject RIV CD - Macromolecular Chemistry R&D Projects IAA400500806 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) KAN200200651 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z40500505 - UMCH-V (2005-2011) AV0Z50200510 - MBU-M (2005-2011) UT WOS 000274186900001 DOI 10.1177/0883911509353485 Annotation The synthesis, physico-chemical behavior, and in vitro intracellular degradation of new biodegradable graft, diblock or multiblock polymer carriers that were designed to deliver bioactive compounds by passive tumor targeting were investigated. In all three carrier systems, the single polymers were linked via biodegradable disulfide bonds forming the graft, diblock or multiblock polymers. Here, degradation of the polymers in model buffer solutions mimicking intracellular environment as well as after incubation with EL4 T-cell lymphoma cancer cells were investigated. In both cases, degradation resulted in polymer fragments of molecular weight below the renal threshold. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2010
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