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High-molecular-weight polymer carriers with degradable disulfide groups: evidence of degradation in vitro
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SYSNO ASEP 0322130 Document Type C - Proceedings Paper (int. conf.) R&D Document Type Conference Paper Title High-molecular-weight polymer carriers with degradable disulfide groups: evidence of degradation in vitro Title Vysokomolekulární polymerní nosiče s degradovatelnými disulfidovými skupinami: prokázání in vitro degradace Author(s) Šubr, Vladimír (UMCH-V) RID, ORCID
Etrych, Tomáš (UMCH-V) RID, ORCID
Kovář, Lubomír (MBU-M)
Braunová, Alena (UMCH-V) RID
Pechar, Michal (UMCH-V) RID, ORCID
Chytil, Petr (UMCH-V) RID, ORCID
Říhová, Blanka (MBU-M) RID
Ulbrich, Karel (UMCH-V) RIDSource Title 14th International Symposium on Recent Advances in Drug Delivery Systems. - Salt Lake City : University of Utah, 2009 Pages s. 193-194 Number of pages 2 s. Action International Symposium on Recent Advances in Drug Delivery Systems /14./ Event date 15.02.2009-18.02.2009 VEvent location Salt Lake City Country US - United States Event type WRD Language eng - English Country US - United States Keywords high-molecular-weight polymer carriers ; N-(2-hydroxypropyl)methacrylamide copolymers ; multiblock PEG Subject RIV CD - Macromolecular Chemistry R&D Projects IAAX00500803 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) IAA400500806 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z40500505 - UMCH-V (2005-2011) AV0Z50200510 - MBU-M (2005-2011) Annotation Water-soluble synthetic polymers have been intensively studied as drug carrier systems for delivery of anticancer therapeutics enabling passive tumor targeting due to EPR effect. Here we describe the synthesis, physico-chemical characteristics and detailed study of degradability of graft, diblock or multiblock HMW polymer carriers based on HPMA copolymers or PEG designed for delivery of drugs by passive tumor targeting. The components of the polymer carriers, grafts, main chains and blocks with molecular weight below 50 000, are linked via spacers containing disulfide groups susceptible to reductive degradation. We have performed in vitro degradation of the polymer carriers in a buffer containing glutathione and compared with that in the presence of EL4 T-lymphoma cancer cells. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2009
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