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Advances in Disease Models

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    0523233 - ÚMG 2020 RIV CZ eng M - Monography Chapter
    Epp, Trevor - Schuster, Bjorn - Chawengsaksophak, Kallayanee
    Visualizing embryonic hematopoiesis in the mouse.
    Advances in Disease Models. Praha: OPTIO CZ, 2019 - (Bartůněk, P.), s. 153-158. ISBN 978-80-88011-06-4
    R&D Projects: GA MŠk LO1419; GA ČR GA17-16959S
    Institutional support: RVO:68378050
    Keywords : developmental hematopoiesis * primitive blood cells * Line3 transgenic reporter line
    Subject RIV: EB - Genetics ; Molecular Biology
    OBOR OECD: Biochemistry and molecular biology

    The Line3 transgenic reporter line was developed as a model to study transgene variegation. Here we show that this mouse line exhibits very bright GFP fluorescence in the earliest primitive blood cells of the developing embryo. Thus this line is also a powerful new model for the study developmental hematopoiesis and vasculogenesis.
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