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Hematopoietic Cytokine Gene Duplication in Zebrafish Erythroid and Myeloid Lineages

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    0501983 - ÚMG 2019 RIV CH eng J - Journal Article
    Oltová, Jana - Svoboda, Ondřej - Bartůněk, Petr
    Hematopoietic Cytokine Gene Duplication in Zebrafish Erythroid and Myeloid Lineages.
    Frontiers in cell and developmental biology. Roč. 6, December (2018), č. článku 174. ISSN 2296-634X
    R&D Projects: GA MŠk LO1419; GA ČR GA16-21024S
    Institutional support: RVO:68378050
    Keywords : zebrafish * hematopoiesis * cytokine * genome duplication * myelopoiesis * erythropoiesis
    Subject RIV: EB - Genetics ; Molecular Biology
    OBOR OECD: Biochemistry and molecular biology
    Impact factor: 5.206, year: 2018

    Hematopoiesis is a precisely orchestrated process regulated by the activity of hematopoietic cytokines and their respective receptors. Due to an extra round of whole genome duplication during vertebrate evolution in teleost fish, zebrafish have two paralogs of many important genes, including genes involved in hematopoiesis. Importantly, these duplication events brought increased level of complexity in such cases, where both ligands and receptors have been duplicated in parallel. Therefore, precise understanding of binding specificities between duplicated ligand-receptor signalosomes as well as understanding of their differential expression provide an important basis for future studies to better understand the role of duplication of these genes. However, although many recent studies in the field have partly addressed functional redundancy or sub-specialization of some of those duplicated paralogs, this information remains to be scattered over many publications and unpublished data. Therefore, the focus of this review is to provide an overview of recent findings in the zebrafish hematopoietic field regarding activity, role and specificity of some of the hematopoietic cytokines with emphasis on crucial regulators of the erythro-myeloid lineages.
    Permanent Link: http://hdl.handle.net/11104/0293946
     
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