Biological effects of static magnetic fields

0571969 - FZÚ 2024 RIV SG eng M - Monography Chapter
Zablotskii, Vitalii - Polyakova, Tetyana - Dejneka, Alexandr
Controlling cell membrane potential with static nonuniform magnetic fields.
Biological effects of static magnetic fields. Singapore: Springer Singapore, 2023 - (Zhang, Y.), s. 113-131. ISBN 978-981-19-8868-4
Institutional support: RVO:68378271
Keywords : cell responses to magnetic fields * membrane potential * ion channels * magnetogenetics
OECD category: Biophysics
https://link.springer.com/chapter/10.1007/978-981-19-8869-1_5

The coordinated activity of a myriad of ion channels in a cell is a spectacular biological and physical phenomenon. Understanding mechanisms governing the ion channel gating and setting membrane potentials is key to developing targeted therapeutic strategies using non-contact magnetic stimulations. In this study, we demonstrate theoretically that ion channel activity can be controlled by a static gradient magnetic field. The analysis revealed that specific ion membrane channels can be turned off and on by remotely applying a high gradient magnetic field, thus modulating the cell membrane potentials. The suggested model and mechanisms provide a general framework for identifying possible hidden mechanisms of biomagnetic effects associated with modulation of ion channel activity by high gradient static magnetic fields.
Permanent Link: https://hdl.handle.net/11104/0342823