Comparison of Transcriptomic Profiles of MiaPaCa-2 Pancreatic Cancer Cells Treated with Different Statins

0555475 - ÚMG 2022 RIV CH eng J - Journal Article
Rimpelová, S. - Kolář, Michal - Strnad, Hynek - Rumlová, T. - Vítek, L. - Gbelcova, H.
Comparison of Transcriptomic Profiles of MiaPaCa-2 Pancreatic Cancer Cells Treated with Different Statins.
Molecules. Roč. 26, č. 12 (2021), č. článku 3528. E-ISSN 1420-3049
R&D Projects: GA MŠMT(CZ) EF16_019/0000785
Institutional support: RVO:68378050
Keywords : statins * pancreatic cancer * DNA microarray * pitavastatin * cerivastatin * simvastatin * fluvastatin * atorvastatin * pravastatin * HMG-CoA reductase inhibitors
OECD category: Biochemistry and molecular biology
Impact factor: 4.927, year: 2021
Method of publishing: Open access
https://www.mdpi.com/1420-3049/26/12/3528

Statins have been widely used for the treatment of hypercholesterolemia due to their ability to inhibit HMG-CoA reductase, the rate-limiting enzyme of de novo cholesterol synthesis, via the so-called mevalonate pathway. However, their inhibitory action also causes depletion of downstream intermediates of the pathway, resulting in the pleiotropic effects of statins, including the beneficial impact in the treatment of cancer. In our study, we compared the effect of all eight existing statins on the expression of genes, the products of which are implicated in cancer inhibition and suggested the molecular mechanisms of their action in epigenetic and posttranslational regulation, and in cell-cycle arrest, death, migration, or invasion of the cancer cells.
Permanent Link: http://hdl.handle.net/11104/0329987