Left Ventricular Myocardial Septal Pacing in Close Proximity to LBB Does Not Prolong the Duration of the Left Ventricular Lateral Wall Depolarization Compared to LBB Pacing

0551968 - ÚPT 2022 RIV CH eng J - Journal Article
Čurila, K. - Jurák, Pavel - Vernooy, K. - Jastrzębski, M. - Waldauf, P. - Prinzen, F. - Halámek, Josef - Sušánková, M. - Znojilová, L. - Smíšek, Radovan - Karch, J. - Plešinger, Filip - Moskal, P. - Heckman, L. - Mizner, J. - Viščor, Ivo - Vondra, Vlastimil - Leinveber, P. - Osmančík, P.
Left Ventricular Myocardial Septal Pacing in Close Proximity to LBB Does Not Prolong the Duration of the Left Ventricular Lateral Wall Depolarization Compared to LBB Pacing.
Frontiers in Cardiovascular Medicine. Roč. 8, 07 December (2021), č. článku 787414. E-ISSN 2297-055X
R&D Projects: GA MZd(CZ) NU21-02-00584
Institutional support: RVO:68081731
Keywords : left bundle branch pacing * left septal myocardial pacing * UHF-ECG * dyssynchrony * depolarization duration
OECD category: Cardiac and Cardiovascular systems
Impact factor: 5.848, year: 2021
Method of publishing: Open access
https://www.frontiersin.org/articles/10.3389/fcvm.2021.787414/full

Background: Three different ventricular capture types are observed during left bundle branch pacing (LBBp). They are selective LBB pacing (sLBBp), non-selective LBB pacing (nsLBBp), and myocardial left septal pacing transiting from nsLBBp while decreasing the pacing output (LVSP). Study aimed to compare differences in ventricular depolarization between these captures using ultra-high-frequency electrocardiography (UHF-ECG).Methods: Using decremental pacing voltage output, we identified and studied nsLBBp, sLBBp, and LVSP in patients with bradycardia. Timing of ventricular activations in precordial leads was displayed using UHF-ECGs, and electrical dyssynchrony (e-DYS) was calculated as the difference between the first and last activation. The durations of local depolarizations (Vd) were determined as the width of the UHF-QRS complex at 50% of its amplitude.Results: In 57 consecutive patients, data were collected during nsLBBp (n = 57), LVSP (n = 34), and sLBBp (n = 23). Interventricular dyssynchrony (e-DYS) was significantly lower during LVSP16 ms (-21, 11), than nsLBBp24 ms (-28, 20) and sLBBp31 ms (-36, 25). LVSP had the same V1d-V8d as nsLBBp and sLBBp except for V3d, which during LVSP was shorter than sLBBp, the mean difference9 ms (-16, 1), p = 0.01. LVSP caused less interventricular dyssynchrony and the same or better local depolarization durations than nsLBBp and sLBBp irrespective of QRS morphology during spontaneous rhythm or paced QRS axis.Conclusions: In patients with bradycardia, LVSP in close proximity to LBB resulted in better interventricular synchrony than nsLBBp and sLBBp and did not significantly prolong depolarization of the left ventricular lateral wall.
Permanent Link: http://hdl.handle.net/11104/0327165