The Effect of Chemical Structure of OEG Ligand Shells with Quaternary Ammonium Moiety on the Colloidal Stabilization, Cellular Uptake and Photothermal Stability of Gold Nanorods

0544878 - ÚMG 2022 RIV NZ eng J - Journal Article
Salajková, Šárka - Havel, Filip - Šrámek, Michal - Novotný, Filip - Malinak, D. - Doležal, R. - Prchal, L. - Benková, M. - Soukup, O. - Musílek, K. - Kuca, K. - Bártek, Jiří - Proska, J. - Žárská, Monika - Hodný, Zdeněk
The Effect of Chemical Structure of OEG Ligand Shells with Quaternary Ammonium Moiety on the Colloidal Stabilization, Cellular Uptake and Photothermal Stability of Gold Nanorods.
International Journal of Nanomedicine. Roč. 16, May (2021), s. 3407-3427. E-ISSN 1178-2013
R&D Projects: GA ČR GA16-13967S; GA MZd NV19-08-00523; GA MŠMT(CZ) LM2015062; GA MŠMT(CZ) LM2015062; GA MŠMT(CZ) EF16_013/0001775
Institutional support: RVO:68378050
Keywords : gold nanorods * quaternary ammonium salts * oligoethylene glycol * cellular uptake * photothermal stability
OECD category: Pharmacology and pharmacy
Impact factor: 7.033, year: 2021
Method of publishing: Open access
https://www.dovepress.com/the-effect-of-chemical-structure-of-oeg-ligand-shells-with-quaternary--peer-reviewed-fulltext-article-IJN

Purpose: Plasmonic photothermal cancer therapy by gold nanorods (GNRs) emerges as a promising tool for cancer treatment. The goal of this study was to design cationic oligoethylene glycol (OEG) compounds varying in hydrophobicity and molecular electrostatic potential as ligand shells of GNRs. Three series of ligands with different length of OEG chain (ethylene glycol units = 3, 4, 5) and variants of quaternary ammonium salts (QAS) as terminal functional group were synthesized and compared to a prototypical quaternary ammonium ligand with alkyl chain (16-mercaptohexadecyl)trimethylammonium bromide (MTAB).
Permanent Link: http://hdl.handle.net/11104/0321676