Cell-autonomous hepatocyte-specific GP130 signaling is sufficient to trigger a robust innate immune response in mice

0544578 - ÚMG 2022 RIV NL eng J - Journal Article
Schumacher, N. - Yan, K. - Gandrass, M. - Mueller, M. - Krisp, C. - Haesler, R. - Carambia, A. - Nofer, J.R. - Bernardes, J.P. - Khouja, M. - Thomsen, I. - Chalupský, Karel - Bolik, J. - Hoelscher, C. - Wunderlich, T. - Herkel, J. - Rosenstiel, P. - Schramm, C. - Schlueter, H. - Renne, T. - Mittruecker, H.W. - Rose-John, S. - Schmidt-Arras, D.
Cell-autonomous hepatocyte-specific GP130 signaling is sufficient to trigger a robust innate immune response in mice.
Journal of Hepatology. Roč. 74, č. 2 (2021), s. 407-418. ISSN 0168-8278. E-ISSN 1600-0641
Institutional support: RVO:68378050
Keywords : il-6 * gp130 * Acute-phase response * Innate immunity
OECD category: Cell biology
Impact factor: 30.083, year: 2021
Method of publishing: Limited access
https://www.journal-of-hepatology.eu/article/S0168-8278(20)33664-3/fulltext

Background & Aims: Interleukin (IL)-6 cytokine family members contribute to inflammatory and regenerative processes. Engagement of the signaling receptor subunit gp130 is common to almost all members of the family. In the liver, all major cell types respond to IL-6-type cytokines, making it difficult to delineate cell type-specific effects. We therefore generated mouse models for liver cell type-specific analysis of IL-6 signaling.
Permanent Link: http://hdl.handle.net/11104/0321421