Potent Cyclic Tetrapeptide for Lead Detoxification

0542235 - ÚOCHB 2022 RIV DE eng J - Journal Article
Mohammed, T. A. - Meier, C. M. - Kalvoda, Tadeáš - Kalt, M. - Rulíšek, Lubomír - Shoshan, M. S.
Potent Cyclic Tetrapeptide for Lead Detoxification.
Angewandte Chemie - International Edition. Roč. 60, č. 22 (2021), s. 12381-12385. ISSN 1433-7851. E-ISSN 1521-3773
R&D Projects: GA ČR(CZ) GA20-08772S
Institutional support: RVO:61388963
Keywords : chelation therapy * lead poisoning * metal selectivity * peptides * rational design
OECD category: Physical chemistry
Impact factor: 16.823, year: 2021
Method of publishing: Limited access
https://doi.org/10.1002/anie.202103217

Lead (Pb) is a ubiquitous poisonous metal, affecting the health of vast populations worldwide. Medications to treat Pb poisoning suffer from various limitations and are often toxic owing to insufficient metal selectivity. Here, we report a cyclic tetrapeptide that selectively binds Pb and eradicates its toxic effect on the cellular level, with superior potency than state‐of‐the‐art drugs. The Pb‐peptide complex is remarkably strong and was characterized experimentally and computationally. Accompanied by the lack of toxicity and enhanced stability of this peptide, these qualities indicate its merit as a potential remedy for Pb poisoning.
Permanent Link: http://hdl.handle.net/11104/0319700