Reversible multilayered vesicle-like structures with fluid hydrophobic and interpolyelectrolyte layers

0542110 - ÚMCH 2022 RIV US eng J - Journal Article
Murmiliuk, A. - Filippov, S. K. - Rud, O. - Košovan, P. - Tošner, Z. - Radulescu, A. - Skandalis, A. - Pispas, S. - Šlouf, Miroslav - Štěpánek, M.
Reversible multilayered vesicle-like structures with fluid hydrophobic and interpolyelectrolyte layers.
Journal of Colloid and Interface Science. Roč. 599, October (2021), s. 313-325. ISSN 0021-9797. E-ISSN 1095-7103
R&D Projects: GA ČR(CZ) GA19-10429S
Institutional support: RVO:61389013
Keywords : electrostatic coassembly * block polyelectrolytes * core/shell particles
OECD category: Physical chemistry
Impact factor: 9.965, year: 2021
Method of publishing: Limited access
https://www.sciencedirect.com/science/article/pii/S002197972100552X

Hydrophobic blocks of amphiphilic block copolymers often form glassy micellar cores at room temperature with a rigid structure that limits their applications as nanocapsules for targeted delivery. Nevertheless, we prepared and analyzed core/shell micelles with a soft core, formed by a self-assembled block copolymer consisting of a hydrophobic block and a polycation block, poly(lauryl acrylate)-block-poly(trimethyl-aminoethyl acrylate) (PLA-QPDMAEA), in aqueous solution. By light and small-angle neutron scattering, by transmission electron microscopy and by fluorescence spectroscopy, we showed that these core/shell micelles are spherical and cylindrical with a fluid-like PLA core and a positively charged outer shell and that they can encapsulate and release hydrophobic solutes. Moreover, after mixing these PLA-QPDMAEA core/shell micelles with another diblock copolymer, consisting of a hydrophilic block and a polyanion block, namely poly(ethylene oxide)-block-poly(methacrylic acid) (PEO-PMAA), we observed the formation of novel vesicle-like multicompartment structures containing both soft hydrophobic and interpolyelectrolyte (IPEC) layers. By combining small-angle neutron scattering with self-consistent field modeling, we confirmed the formation of these complex vesicle-like structures with a swollen PEO core, an IPEC inner layer, a PLA soft layer, an IPEC outer layer and a loose PEO corona. Thus, these multicompartment micelles with fluid and IPEC layers and a hydrophilic corona may be used as nanocapsules with several tunable properties, including the ability to control the thickness of each layer, the charge of the IPEC layers and the stability of the micelles, to deliver both hydrophobic and multivalent solutes.
Permanent Link: http://hdl.handle.net/11104/0319789