Dihydroorotate dehydrogenase in oxidative phosphorylation and cancer

0525375 - BTÚ 2021 RIV NL eng J - Journal Article
Boukalová, Štěpána - Hubáčková, Soňa - Miloševič, Mirko - Ezrová, Zuzana - Neužil, Jiří - Rohlena, Jakub
Dihydroorotate dehydrogenase in oxidative phosphorylation and cancer.
Biochimica Et Biophysica Acta-Molecular Basis of Disease. Roč. 1866, č. 6 (2020), č. článku 165759. ISSN 0925-4439. E-ISSN 1879-260X
R&D Projects: GA ČR GA19-20553S; GA ČR(CZ) GA20-18513S; GA ČR(CZ) GA18-02550S; GA ČR(CZ) GJ20-11724Y; GA ČR(CZ) GC17-01192J; GA ČR(CZ) GA18-10832S; GA MŠMT(CZ) ED1.1.00/02.0109
Institutional support: RVO:86652036
Keywords : Dehydroorotate dehydrogenase * Oxidative phosphorylation * Cancer
OECD category: Biochemistry and molecular biology
Impact factor: 5.187, year: 2020
Method of publishing: Open access
https://www.sciencedirect.com/science/article/pii/S0925443920301046?via%3Dihub

Dihydroorotate dehydrogenase (DHODH) is an enzyme of the de novo pyrimidine synthesis pathway that provides nucleotides for RNA/DNA synthesis essential for proliferation. In mammalian cells, DHODH is localized in mitochondria, linked to the respiratory chain via the coenzyme Q pool. Here we discuss the role of DHODH in the oxidative phosphorylation system and in the initiation and progression of cancer. We summarize recent findings on DHODH biology, the progress made in the development of new, specific inhibitors of DHODH intended for cancer therapy, and the mechanistic insights into the consequences of DHODH inhibition.
Permanent Link: http://hdl.handle.net/11104/0309534