Statistical methods for constructing gestational age-related charts for fetal size and pregnancy dating using longitudinal data

0493802 - ÚI 2019 RIV PL eng J - Journal Article
Hynek, M. - Kalina, Jan - Zvárová, Jana - Long, J. D.
Statistical methods for constructing gestational age-related charts for fetal size and pregnancy dating using longitudinal data.
Biocybernetics and Biomedical Engineering. Roč. 38, č. 4 (2018), s. 992-1003. ISSN 0208-5216. E-ISSN 0208-5216
Institutional support: RVO:67985807
Keywords : Fetal size * Fetal reference charts * Longitudinal data * Mixed effects models * Regression quantiles * Multimodel inference
OECD category: Statistics and probability
Impact factor: 2.159, year: 2018

The assessment of fetal size and the accurate estimation of gestational age are of crucial importance for proper pregnancy management. The information is almost exclusively based on ultrasound measurements of fetal biometric parameters and the means for evaluating these measurements are age-related reference charts (centile charts) allowing interpretation of obtained fetal measurement in comparison with the expected average measurement in the reference population. The construction of such reference charts requires an appropriate statistical methodology. The most frequent method for the construction of fetal reference charts from cross-sectional data is the parametric approach with fractional polynomials regression functions for the mean and standard deviation of each fetal measurement. This article suggests how this method can be extended to longitudinal data using fractional polynomials in linear mixed effect regression. The presented approach includes maximum likelihood estimation for fitting first- and second-order fractional polynomial models, and multimodel inference using Akaike's information criterion and related tools as a suitable strategy for model selection. Finally, an example of the suggested approach is presented.
Permanent Link: http://hdl.handle.net/11104/0287103