Molecular Mechanisms of Skin Aging and Age-Related Diseases

0473322 - ÚMG 2017 RIV US eng M - Monography Chapter
Krejčí, E. - Dvořánková, B. - Szabo, P. - Naňka, O. - Strnad, Hynek - Kodet, O. - Lacina, L. - Kolář, Michal - Smetana, K.
Fibroblasts as Drivers of Healing and Cancer Progression:From In vitro Experiments to Clinics.
Molecular Mechanisms of Skin Aging and Age-Related Diseases. Boca Raton: CRC Press, 2016, s. 121-138. ISBN 978-1-4987-0464-9
Institutional support: RVO:68378050
Keywords : Fibroblasts * Cancer Progression * In vitro Experiments
Subject RIV: EB - Genetics ; Molecular Biology

Tissues and organs are composed of cells as building stones. Biased by
previous education in classical descriptive histology, we tend to see tissues
as fairly stable structures. We admit certain dynamics and rapid changes
during the lifetime especially through growth period of childhood and also
in lesser extent during normal ageing. The reality is far more different. All
the seeming tissue stability is resulting from a very complex orchestration
of various, frequently counteracting, events. All the cells located in distinct
types of tissues and organs, including skin, are participating on those events by mutual crosstalk mediated by numerous molecular messengers.
This extensive conversation is conveyed by growth factors and molecules of
extracellular matrix and reflects the actual position of an individual in wide
ontogeny from prenatal stages of life till decease. Precise deciphering of this
message can be complicated as individual components frequently reveal
great context dependency. The crosstalk integrates internal impulses from
the body and exogenous stimuli from the macroenvironment, including
the interactions with e.g. microorganisms. Harmony of these signals and
the optimal cellular response is necessary for the maintenance of proper
homeostasis of the whole organism.
The progress of research in normal-tissue/cancer stem cells has resulted
in a remarkable accumulation of scientific data on the influence of the
microenvironment on cellular function. This chapter summarizes data on
the intercellular interactions in human skin and other squamous epithelia
and focuses predominantly on the role of fibroblasts in the course of wound
healing and cancer formation.
Permanent Link: http://hdl.handle.net/11104/0270471