0466479 - FGÚ 2017 RIV US eng J - Journal Article
Franco, R. - Casadó-Anguera, V. - Muňoz, A. - Petrovič, Miloš - Navarro, G. - Moreno, E. - Lanciego, J. L. - Labandeira-García, J. L. - Cortés, A. - Casadó, V.
Hints on the Lateralization of Dopamine Binding to D-1 Receptors in Rat Striatum.
Molecular Neurobiology. Roč. 53, č. 8 (2016), s. 5436-5445. ISSN 0893-7648. E-ISSN 1559-1182
Institutional support: RVO:67985823
Keywords : lateralization * basal ganglia * G-protein-coupled receptor dimer * dyskinesia * 6-hydroxydopamine
Subject RIV: ED - Physiology
Impact factor: 6.190, year: 2016 ; AIS: 1.477, rok: 2016
DOI: https://doi.org/10.1007/s12035-015-9468-8

Dopamine receptors in striatum are important for healthy brain functioning and are the target of levodopa-based therapy in Parkinson's disease. Lateralization of dopaminergic neurotransmission in striata from different hemispheres occurs in patients, but also in healthy individuals. Our data show that the affinity of dopamine binding to dopamine D-1 receptors is significantly higher in left than in right striatum. Analysis of data from radioligand binding to striatal samples from na < ve, 6-hydroxydopamine lesioned, levodopa-treated and levodopa-induced dyskinetic rats shows differential receptor structure and gives hints on the causes of right/left lateralization of dopamine binding to striatal D-1 receptors. Moreover, binding data showed loss of lateralization in levodopa (L-DOPA)-induced dyskinetic rats.
Permanent Link: http://hdl.handle.net/11104/0264759