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Recent developments and applications of capillary and microchip electrophoresis in proteomic and peptidomic analyses
- 1.0458688 - ÚOCHB 2017 RIV DE eng J - Journal Article
Štěpánová, Sille - Kašička, Václav
Recent developments and applications of capillary and microchip electrophoresis in proteomic and peptidomic analyses.
Journal of Separation Science. Roč. 39, č. 1 (2016), s. 198-211. ISSN 1615-9306. E-ISSN 1615-9314
R&D Projects: GA ČR(CZ) GA13-17224S; GA ČR(CZ) GA15-01948S
Institutional support: RVO:61388963
Keywords : capillary electrophoresis * mass spectrometry * microchip electrophoresis * peptidomics * proteomics
Subject RIV: CB - Analytical Chemistry, Separation
Impact factor: 2.557, year: 2016
This review presents recent developments and applications of capillary and microchip electromigration methods in proteomics and peptidomics. Sample preparation methods as well as instrumental innovations in the coupling of these advanced electromigration methods with mass spectrometry detection employed in proteomic and peptidomic analyses are presented. Interesting applications of various capillary electromigration methods in bottom-up as well as top-down proteomics, including investigation of post-translational modifications of proteins are described. In addition, several examples of the use of capillary electromigration methods combined with mass spectrometry detection in clinical proteomics and peptidomics are demonstrated.
Permanent Link: http://hdl.handle.net/11104/0258941
Number of the records: 1