Origins of the Vertebrate Erythro/Megakaryocytic System

0455878 - ÚMG 2016 RIV US eng J - Journal Article
Svoboda, Ondřej - Bartůněk, Petr
Origins of the Vertebrate Erythro/Megakaryocytic System.
BioMed Research International. Roč. 2015, Oct 18 (2015). ISSN 2314-6133. E-ISSN 2314-6141
R&D Projects: GA MŠMT LO1419
Institutional support: RVO:68378050
Keywords : erythrocytes * thrombocytes * vertebrate Erythro/Megakaryocytic System * progenitors
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 2.134, year: 2015

Vertebrate erythrocytes and thrombocytes arise from the common bipotent thrombocytic-erythroid progenitors (TEPs). Even though nonmammalian erythrocytes and thrombocytes are phenotypically very similar to each other, mammalian species have developed some key evolutionary improvements in the process of erythroid and thrombocytic differentiation, such as erythroid enucleation, megakaryocyte endoreduplication, and platelet formation. This brings up a few questions that we try to address in this review. Specifically, we describe the ontology of erythro-thrombopoiesis during adult hematopoiesis with focus on the phylogenetic origin of mammalian erythrocytes and thrombocytes (also termed platelets). Although the evolutionary relationship between mammalian and nonmammalian erythroid cells is clear, the appearance of mammalian megakaryocytes is less so. Here, we discuss recent data indicating that nonmammalian thrombocytes and megakaryocytes are homologs. Finally, we hypothesize that erythroid and thrombocytic differentiation evolved from a single ancestral lineage, which would explain the striking similarities between these cells.
Permanent Link: http://hdl.handle.net/11104/0256478