Water-soluble octahedral molybdenum cluster compounds Na2[Mo6I8(N3)6] and Na2[Mo6I8(NCS)6]: Syntheses, luminescence, and in vitro studies

0452507 - ÚACH 2016 RIV NL eng J - Journal Article
Kirakci, Kaplan - Kubát, Pavel - Kučeráková, Monika - Šícha, Václav - Gbelcová, H. - Lovecká, P. - Grznárová, P. - Ruml, T. - Lang, Kamil
Water-soluble octahedral molybdenum cluster compounds Na2[Mo6I8(N3)6] and Na2[Mo6I8(NCS)6]: Syntheses, luminescence, and in vitro studies.
Inorganica chimica acta. Roč. 441, FEB (2016), s. 42-49. ISSN 0020-1693. E-ISSN 1873-3255
R&D Projects: GA ČR GA13-05114S
Institutional support: RVO:61388980 ; RVO:61388955 ; RVO:68378271
Keywords : Cluster compounds * Luminescence * Singlet oxygen * Toxicity
Subject RIV: CA - Inorganic Chemistry; CF - Physical ; Theoretical Chemistry (UFCH-W); CF - Physical ; Theoretical Chemistry (FZU-D)
Impact factor: 2.002, year: 2016

The octahedral molybdenum cluster compounds Na2[Mo6I8(N3)6] and Na2[Mo6I8(NCS)6] were synthesized and their luminescent properties and biological activity were investigated. Most molybdenum cluster compounds reported so far have had low solubility in water and/or underwent hydrolysis connected with aggregation, sedimentation, and diminishing luminescence and singlet oxygen-sensitizing properties. This behavior prevented the investigation of their photophysical properties and in vitro biological activities in aqueous media. Title compounds behave differently. They are well soluble in water and have red luminescence, which is quenched by oxygen to produce singlet oxygen, O2(1Δg), in high quantum yields. Even though [Mo6I8(N3)6]2− and [Mo6I8(NCS)6]2− gradually hydrolyze to mono-hydroxy derivatives, they do not form sedimenting aggregates, luminescence properties are well-defined, and the quantum yields of O2(1Δg) remain unchanged. These attractive features, suitable for luminescent probes or O2(1Δg) sensitizers in living cells, are overshadowed by the toxicity, especially of [Mo6I8(NCS)6]2−, and by the limited uptake by the HeLa and HEK 293T cell lines.

Permanent Link: http://hdl.handle.net/11104/0253538


Research data: CCDC, CCDC