Increased Sensitivity of the Circadian System to Temporal Changes in the Feeding Regime of Spontaneously Hypertensive Rats - A Potential Role for Bmal2 in the Liver

0396915 - FGÚ 2014 RIV US eng J - Journal Article
Polidarová, Lenka - Sládek, Martin - Nováková, Marta - Parkanová, Daniela - Sumová, Alena
Increased Sensitivity of the Circadian System to Temporal Changes in the Feeding Regime of Spontaneously Hypertensive Rats - A Potential Role for Bmal2 in the Liver.
PLoS ONE. Roč. 8, č. 9 (2013), e75690. ISSN 1932-6203. E-ISSN 1932-6203
R&D Projects: GA ČR(CZ) GAP303/11/0668
Institutional support: RVO:67985823
Keywords : circadian * clock gene * metabolism * liver * feeding regime * Bmal2 * spontaneously hypertensive rat
Subject RIV: ED - Physiology
Impact factor: 3.534, year: 2013

Sensitivity of the circadian system to temporal change in feeding regime is higher in spontaneously hypertensive rats (SHR) than in controls. At the behavioral level, SHR develop faster food anticipatory activity than control rats and shift completely their locomotor activity rhythm. At the molecular level, their peripheral clock in the liver exhibits larger phase shift due to the change in feeding regime. The results suggested possible involvement of Bmal2 gene in the higher sensitivity of the SHR hepatic clock to the metabolic challenge
Permanent Link: http://hdl.handle.net/11104/0224626