Human conditionally immortalized neural stem cells improve locomotor function after spinal cord injury in the rat

0396554 - ÚEM 2014 RIV GB eng J - Journal Article
Amemori, Takashi - Romanyuk, Nataliya - Jendelová, Pavla - Herynek, V. - Turnovcová, Karolína - Procházka, Pavel - Kapcalová, Miroslava - Cocks, G. - Price, J. - Syková, Eva
Human conditionally immortalized neural stem cells improve locomotor function after spinal cord injury in the rat.
Stem Cell Research & Therapy. Roč. 4, č. 3 (2013), s. 68. E-ISSN 1757-6512
R&D Projects: GA ČR(CZ) GAP304/12/1370; GA ČR GA13-00939S; GA MŠMT LH12024; GA ČR(CZ) GBP304/12/G069
Grant - others:GA MZd(CZ) 00023001IKEM
Institutional support: RVO:68378041
Keywords : human fetal neural stem cells * spinal cord injury * motor neuron differentiation
Subject RIV: FH - Neurology
Impact factor: 4.634, year: 2013

A conditionally immortalized neural stem cell line derived from human fetal spinal cord tissue (SPC-01) were implanted into rat spinal corf injury. The transplantation of SPC-01 cells produced significant early functional improvement after SCI, suggesting an early neurotrophic action associated with long term restoration of the host tissue, making the cells a promising candidate for future cell therapy.
Permanent Link: http://hdl.handle.net/11104/0224306