Polymorphisms in DNA repair genes, recreational physical activity and breast cancer risk

0395393 - ÚEM 2015 RIV DE eng J - Journal Article
McCullough, L. E. - Santella, R. M. - Cleveland, R. J. - Millikan, R. C. - Olshan, A. F. - North, K. E. - Bradshaw, P. T. - Eng, S. M. - Terry, M. B. - Shen, J. - Crew, C. D. - Rössner ml., Pavel - Teitelbaum, S. L. - Neugut, A. I. - Grammon, M. D.
Polymorphisms in DNA repair genes, recreational physical activity and breast cancer risk.
International Journal of Cancer. Roč. 134, č. 3 (2014), s. 654-663. ISSN 0020-7136. E-ISSN 1097-0215
Grant - others:National Institute of Environmental Health Sciences(US) P30ES009089; National Institute of Environmental Health Sciences(US) P30ES10126; Department of Defense Breast Cancer Research Program(US) BC093608; National Institute of Environmental Health Sciences(US) UO1CA/ES66572
Institutional support: RVO:68378041
Keywords : breast cacner * epidemiology * DNA repair
Subject RIV: DN - Health Impact of the Environment Quality
Impact factor: 5.085, year: 2014

Polymorphisms in MMR (mismatch repair) or other DNA repair gene variants may modify the association between recreational physical activity (RPA) and breast cancer incidence. In this study, the individual and joint effects of variants in three MMR pathway genes (MSH3, MLH1 and MSH2) on breast cancer occurence using resources from the Long Island Breast Cancer Study Project were investigated. Additionally, the interactions between RPA and genetic polymorphisms in MMR, BER (base excision repair) and NER (nucleotide excision repair) pathways were characterized. Obtained data show that women with minor alleles in both MSH2 and MLH1 could be at increased breast cancer risk. RPA may be modified by genes in the DNA repair pathway, and merit further investigation.
Permanent Link: http://hdl.handle.net/11104/0226176