Behavioral, neurochemical and pharmaco-EEG profiles of the psychedelic drug 4-bromo-2,5-dimethoxyphenethylamine (2C-B) in rats

0392579 - FGÚ 2014 RIV US eng J - Journal Article
Páleníček, T. - Fujáková, M. - Brunovský, M. - Horáček, J. - Gorman, I. - Balíková, M. - Rambousek, Lukáš - Syslová, K. - Kačer, P. - Zach, P. - Bubeníková-Valešová, V. - Tylš, F. - Kubešová, A. - Puskarčíková, J. - Höschl, C.
Behavioral, neurochemical and pharmaco-EEG profiles of the psychedelic drug 4-bromo-2,5-dimethoxyphenethylamine (2C-B) in rats.
Psychopharmacology. Roč. 225, č. 1 (2013), s. 75-93. ISSN 0033-3158. E-ISSN 1432-2072
R&D Projects: GA MŠMT(CZ) 1M0517
Institutional research plan: CEZ:AV0Z50110509
Keywords : 4-Bromo-2,5-dimethoxyphenethylamine (2C-B) * amphetamine * serotonin * dopamine * nucleus accumbens * behavior * microdialysis * EEG power spectra * EEG coherence * rats
Subject RIV: FH - Neurology
Impact factor: 3.988, year: 2013

2C-B is a centrally active compound similar to other hallucinogens, entactogens and stimulants. Increased dopamine and decreased DOPAC in the NAc may reflect its psychotomimetic and addictive potential and monoaminoxidase inhibition. Alterations in brain functional connectivity reflected the behavioral and neurochemical changes produced by the drug; a correlation between EEG changes and locomotor behavior was observed
Permanent Link: http://hdl.handle.net/11104/0221882