Gene expression changes in human prostate carcinoma cells exposed to genotoxic and nongenotoxic aryl hydrocarbon receptor ligands

0368757 - BFÚ 2012 RIV IE eng J - Journal Article
Hrubá, E. - Vondráček, Jan - Líbalová, Helena - Topinka, Jan - Bryja, Vítězslav - Souček, Karel - Machala, M.
Gene expression changes in human prostate carcinoma cells exposed to genotoxic and nongenotoxic aryl hydrocarbon receptor ligands.
Toxicology Letters. Roč. 206, č. 2 (2011), s. 178-188. ISSN 0378-4274. E-ISSN 1879-3169
R&D Projects: GA ČR(CZ) GA310/07/0961; GA ČR(CZ) GA524/09/1337
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702; CEZ:AV0Z50390512; CEZ:AV0Z50390703
Keywords : LNCaP cells * AhR ligands * WNT5A
Subject RIV: BO - Biophysics
Impact factor: 3.230, year: 2011

The results of the present study showed that effects of model genotoxic and nongenotoxic AhR ligands on global changes in gene expression in LNCaP cells significantly overlap, thus suggesting that the activation of AhR plays a prominent role in the nongenotoxic effects of BaP in the prostate carcinoma cell model. We identified Wnt5a, an important regulator of prostate cancer progression, to be induced after exposure to both AhR ligands, which may further contribute to enhanced cell plasticity of prostate carcinoma cells.
Permanent Link: http://hdl.handle.net/11104/0203013