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Lower sensitivity of FHC fetal colon epithelial cells to photodynamic therapy compared to HT-29 colon adenocarcinoma cells despite higher intracellular accumulation of hypericin
- 1.0366149 - BFÚ 2012 RIV GB eng J - Journal Article
Mikeš, J. - Hýžďalová, Martina - Kočí, Lenka - Jendželovský, R. - Koval, J. - Vaculová, Alena - Hofmanová, Jiřina - Kozubík, Alois - Fedoročko, P.
Lower sensitivity of FHC fetal colon epithelial cells to photodynamic therapy compared to HT-29 colon adenocarcinoma cells despite higher intracellular accumulation of hypericin.
Photochemical & Photobiological Sciences. Roč. 10, č. 4 (2011), s. 626-632. ISSN 1474-905X. E-ISSN 1474-9092
R&D Projects: GA ČR(CZ) GA301/07/1557
Grant - others:GA ČR(CZ) GA305/09/1526
Program: GA
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Keywords : photodynamic therapy * hypericin * colon cancer
Subject RIV: BO - Biophysics
Impact factor: 2.584, year: 2011
Hypericin (HY) has found applications in photodynamic diagnostics solely due to its high specificity for tumour cells and tissues. We showed that despite the higher accumulation of HY in FHC human fetal colon epithelial cells compared to HT-29 colon adenocarcinoma cells, the cytotoxic effects of this photosensitizer were more pronounced in the latter cell line, and this was associated with enhanced accumulation of HY-induced reactive oxygen species (ROS).
Permanent Link: http://hdl.handle.net/11104/0201224
Number of the records: 1